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The alcohol can be converted into a good leaving group by reacting with mesyl chloride (MsCl) or tosyl chloride (TsCl) in the presence of base.

The alcohol performs a substitution reaction on sulfur, causing the formation of an O-S bond and the breaking of the S-Cl bond.

Subsequently, deprotonation of the positively charged alcohol leads to the neutral mesylate or tosylate.

	Alcohol to a leaving group (OTs, OMs)

	The alcohol can be converted into a good leaving group by reacting with mesyl chloride (MsCl) or tosyl chloride (TsCl) in the presence of base. Mechanism The alcohol performs a substitution reaction on sulfur, causing the formation of an O-S bond and the breaking of the S-Cl bond. Subsequently, deprotonation of the positively charged alcohol leads to the neutral mesylate or tosylate.